Last modified: 26th April 2023
The PKU diet puts patients at risk of vitamin B12 deficiency; nitrous oxide should be used with caution.
These patients may be at risk of propofol infusion syndrome.
Oral medications containing gelatin or aspartame should be avoided due to their high phenylalanine content.
Reducing the substrate available to form propionic acid is the main focus for perioperative care.
Substrates include: protein catabolism due to fasting, certain neuromuscular blocking drugs, NSAIDS, and propofol.
These patients are at risk of QT prolongation.
Propofol has been used safely as a bolus and brief infusion, but prolonged infusion should be used with caution.