Last modified: 26th April 2023
Using nitrous oxide may exacerbate high homocysteine levels in classical homocysteinuria.
In related conditions such as MTHFR deficiency, nitrous oxide use can result in fatal neurological deterioration.
The PKU diet puts patients at risk of vitamin B12 deficiency; nitrous oxide should be used with caution.
These patients may be at risk of propofol infusion syndrome.
Oral medications containing gelatin or aspartame should be avoided due to their high phenylalanine content.