McArdle disease

Last modified: 29th March 2023

Strong association with:
Rhabdomyolysis

Potentially implicated drugs:

Desflurane

Enflurane

Halothane

Isoflurane

Sevoflurane

Suxamethonium

Overview

Muscle phosphorylase deficiency, glycogen storage disease V.

Exercise intolerance during sport or physical activity, premature fatigue, myalgia, cramps, and myoglobinuria.

Rhabdomyolysis

Risk of rhabdomyolysis with exposure to volatile anaesthesia or suxamethonium

McArdle's disease and anaesthesia: case reports. Review of potential problems and association with malignant hyperthermia

ACTA Anaesthesiologica Scandinavica 2005