Duchenne muscular dystrophy
Also known as:
DMD
Duchenne muscular dystrophy
Duchenne muscular dystrophy
Last modified: 29th March 2023
Strong association with:
Anaesthetic-induced rhabdomyolysis
Implicated drugs:
Enflurane
Halothane
Isoflurane
Sevoflurane
Theoretical association with:
Overview
Duchenne muscular dystrophy (DMD) is a severe type of muscular dystrophy that primarily affects boys. Muscle weakness usually begins around the age of four, and worsens quickly. Muscle loss typically occurs first in the thighs and pelvis followed by the arms.
Dystrophinopathies
Muscular dystrophy is a group of inherited diseases characterised by weakness and wasting away of muscle tissue, with or without the breakdown of nerve tissue. There are 9 types of muscular dystrophy, with each type involving an eventual loss of strength, increasing disability, and possible deformity. The most well known of the muscular dystrophies is Duchenne muscular dystrophy (DMD), followed by Becker muscular dystrophy (BMD).
Anaesthetic-Induced Rhabdomyolysis
Care should be taken with volatile anaesthetic agents and suxamethonium in all patients with dystrophinopathies.
Rhabdomyolysis in association with Duchenne's muscular dystrophy
Canadian Journal of Anaesthesia 1999
Anesthesia-induced rhabdomyolysis in infants with unsuspected Duchenne dystrophy
Acta Paediatrica 1992
Hyperkalaemic cardiac arrest in a manifesting carrier of Duchenne muscular dystrophy following general anaesthesia
European Journal of Pediatrics 2001
The postoperative cardiovascular arrest of a 5-year-old male: an initial presentation of Duchenne's muscular dystrophy
Paediatric Anaesthesia 2006
Inhalation anesthetics and Duchenne's muscular dystrophy
Canadian Journal of Anaesthesia 1999
Inhalation anesthetics and Duchenne's muscular dystrophy
Canadian Journal of Anaesthesia 1999