Carnitine palmitoyl transferase type 2 deficiency

Last modified: 5th February 2023

Strong association with:
Rhabdomyolysis

Implicated drugs:

Desflurane

Enflurane

Halothane

Isoflurane

Sevoflurane

Suxamethonium

Overview

Muscle weakness or cramps, exercise intolerance. Sometimes associated with rhabdomyolysis.

Rhabdomyolysis

Risk of rhabdomyolysis when exposed to volatiles or suxamethonium in setting of increased background risk

Malignant hyperthermia-like syndrome and carnitine palmitoyltransferase II deficiency with heterozygous R503C mutation

Anesthesia & Analgesia 2009